Primary Class of Medications Responsible for Photosensitizing Reactions
(Examples by Generic Name)

Jerome I. Levine, M.S., R.Ph., prepared the following list for the Federal Drug Administration. The list was published under the title "Medications That Increase Sensitivity To Light: A 1990 Listing." The FDA has confirmed this list to be the most recent.

The mention of commercial products, their sources, or their use in connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services.

The following medications have been reported by the U.S. Food and Drug Administration (FDA) as either causing Photosensitivity, Phototoxicity or Photoallergic reactions.

Generic Name
Brand Name
Therapeutic Class
Acetazolamide Diamox Anticonvulsant, Antiglaucoma diuretic
Amiloride + Hydrochlorothizide Moduretic Antihypertensive, Thiazide diuretic
Amiodarone Cordarone (15%) Antiarrhythmic
Amitriptyline Elavil Antidepressant (tricyclic)
Amitriptyline Endep Antidepressant (tricyclic)
Amoxapine Asendin (<1%) Antidepressant (tricyclic)
Astemizole Hismanal Antihistamine
Atenolol + Chlorthalidone Tenoretic Beta-adrenergic blocker Thiazide diuretic
Auranofin Ridaura Antiarthritic, Gold compound
Azatadine Optimine Antihistamine
Azatidine + Pseudoephedrine Trinalin Repetabs Antihistamine, Decongestant
Bendroflumethiazide Naturetin Antihypertensive, Thiazide diuretic
Benzthiazide Exna Antihypertensive, Thiazide diuretic
Bromodiphenhydramine Ambenyl Antihistamine
Brompheniramine Dimetane Antihistamine
Captopril Capoten Antihypertensive
Captopril + Hydrochlorothiazide Capozide Antihypertensive, Thiazide diuretic
Carbamazepine Tegretol Analgesic, Anticonvulsant
Chlordiazepoxide + Amitriptyline Limbitrol Antidepressant (tricyclic) Tranquilizer
Chlorothiazide Diuril Antihypertensive, Thiazide diuretic
Chlorpheniramine Chlorpheniramine Antihistamine
Chlorpheniramin + D-Pseudoephedrine Deconamine Antihistamine, Decongestant
Chlorpheniramine + Phenylpropanolamine Ru-Tuss II Antihistamine, Decongestant
Chlorpromazine Thorazine Antiemetic, Tranquilizer
Chlorpropamide Diabinese Antidiabetic (oral), Sulfonylurea
Chlorprothixene Taractan Antiemetic, Tranquilizer
Chlorthalidone Hygroton Antihypertensive, Thiazide diuretic
Chlorthalidone Thalitone Antihypertensive, Thiazide diuretic
Chlorthalidone + Reserpine Demi-Regroton Antihypertensive, Thiazide diuretic
Chlorthalidone + Reserpine Regroton Antihypertensive, Thiazide diuretic
Ciprofloxacin Cipro (<1%) Anti-infective
Clemastine Tavist Antihistamine
Clofazime Lamprene (<1%) Antibacterial, Antileprosy agent
Clonidine Chlorthalidone + Combipres Antihypertensive, Thiazide diuretic
Coal Tar Estar Gel Antipsoriatic, Eczema
Coal Tar Balnetar Antipsoriatic, Eczema
Contraceptive, oral Estrogen Birth control pill, Female sex hormone
Cromolyn Intal Inhaler Antiasthmatic
Cyclobenzaprine Flexeril Anti-skeletal, Muscle spasms
Cyproheptadine Periactin Antihistamine, Antiserotonergic
Dacarbazine DTIC-Dome Anti-Hodgkin's disease, Antimetabolite
Danazol Danocrine Gonadotropin inhibitor
Demeclocycline Declomycin Antibiotic
Desipramine Norpramin Antidepressant (tricyclic)
Desipramine Pertofrane Antidepressant (tricyclic)
Dexchlorpheniramine Polaramine Antihistamine
Diclofenac Voltaren (<1%) NSAID,* antiarthritic
Diflunisal Dolobid (<1%) NSAID,* antiarthritic
Diltiazem Calcium channel blocker Cardizem (<1%) Antianginal, Antihypertensive
Diphenhydramine Benadryl Antihistamine
Diphenylpyraline Hispril Spansule Antihistamine
Doxepin Sinequan Antidepressant (tricyclic)
Doxycycline Vibramycin Antibiotic
Doxycycline Hyclate Doryx Antibiotic
Enalapril Vasotec Antihypertensive
Enalapril + Hydrochlorothiazide Vaseretic Antihypertensive, Thiazide diuretic
Erythromycin Ethylsuccinate + Pediazole Antibiotic
Estrogens Contraceptive, oral Female sex hormone
Estrogens Estrogens Female sex hormone
Ethionamide Trecator-SC Anti-infective, Antituberculosis
Etretinate Tegison Antipsoriatic
Floxuridine FUDR Injectable Antimetabolite, Antineoplastic
Flucytosine Ancobon Antifungal
Fluorouracil Adrucil Antineoplastic
Fluorouracil Efudex Antineoplastic
Fluorouracil Fluorouracil Antineoplastic
Fluphenazine Prolixin Antipsychotic, Tranquilizer
Fluphenazine Permitil Antipsychotic, Tranquilizer
Flurbiprofen Ansaid NSAID,* antiarthritic
Flutamide Eulexin Antimetastatic (prostatic carcinoma)
Furosemide Lasix Antihypertensive, Diuretic
Gentamicin Garamycin Antibiotic
Glipizide Glucotrol Antidiabetic (oral), Sulfonylurea
Glyburide Diabeta Antidiabetic (oral),
Glyburide Micronase Antidiabetic (oral),
Gold Salts (compounds) Solganal Antiarthritic, Gold compound
Gold Sodium Thiomalate Myochrysine Antiarthritic, Gold compound
Griseofulvin Fulvicin U/F Antibiotic, Antifungal
Griseofulvin Ultramicrosize Grisactin Ultra Antibiotic, Antifungal
Guanethidine + Hydrochlorothiazide Esimil Antihypertensive, Thiazide diuretic
Haloperidol Haldol Antipsychotic, Tranquilizer
Hexachlorophene Phisohex Antibacterial
Hydralazine + Hydrochlorothiazide Apresazide Antihypertensive, Thiazide diuretic
Hydralazine Apresoline-Esidrix Antihypertensive, Thiazide diuretic
Hydrochlorothiazide Esidrix Antihypertensive, Thiazide diuretic
Hydrochlorothiazide Hydrodiuril Antihypertensive, Thiazide diuretic
Hydrochlorothiazide Oretic Antihypertensive, Thiazide diuretic
Hydrochlorothiazide Oreticyl Antihypertensive, + Deserpidine
Hydrochlorothiazide + Triamterene Dyazide Antihypertensive, Thiazide diuretic
Hydrochlorothiazide Maxzide Antihypertensive, Thiazide diuretic
Hydroflumethiazide Diucardin Antihypertensive, Thiazide diuretic
Hydroflumethiazide Saluron Antihypertensive, Thiazide diuretic
Hydroflumethiazide + Reserpine Salutensin/Salutensin-Demi Antihypertensive, Thiazide diuretic
Ibuprofen Advil (<1%) NSAID,* antiarthritic
Ibuprofen Motrin (<1%) NSAID,* antiarthritic
Imipramine Tofranil Antidepressant (tricyclic)
Indapamide Lozol Antihypertensive, Diuretic
Interferon ALFA-2B Intron A (<1%) Antiviral agent
Isocarboxazid Marplan Antidepressant, MAO inhibitor
Isotretinoin Accutane Antiacne
Ketoprofen Orudis (<1%) NSAID,* antiarthritic
Labetalol Normodyne Antihypertensive,Beta- and alpha-adrenergic blocker
Labetalol + Hydrochlorothiazide Normozide Beta- and alpha-adrenergic blocker, Thiazide diuretic
Labetalol + Hydrochlorothiazide Trandate HCT Beta- and alpha-adrenergic blocker, Thiazide diuretic
Lisinopril + Hydrochlorothiazide Prinzide Antihypertensive, Thiazide diuretic
Lisinopril + Hydrochlorothiazide Zestoretic Antihypertensive, Thiazide diuretic
Lovastatin Mevacor Anticholesterol
Maprotiline Ludiomil Antidepressant
Meperidine + Promethiazine Mepergan Narcotic analgesic
Mesoridazine Serentil Antipsychotic, Tranquilizer
Methacycline Rondomycin Antibiotic
Methazolamide Neptazane Antiglaucoma
Methdilazine Tacaryl Antihistamine, Antipruritic
Methotrexate Folex Antimetabolite, Antipsoriatic
Methotrexate Methotrexate Antimetabolite, Antipsoriatic
Methotrexate Mexate & Mexate-AQ Antimetabolite, Antipsoriatic
Methyclothiazide Aquatensen Antihypertensive, Thiazide
Methyclothiazide Enduron Antihypertensive, Thiazide diuretic
Methyclothiazide + Deserpidine Enduronyl Antihypertensive, Thiazide diuretic
Methyclothiazide + Reserpine Diutensen-R Antihypertensive, Thiazide diuretic
Methyldopa + Hydrochlorothiazide Aldoril Antihypertensive, Thiazide diuretic
Methyldopa + Chlorothiazide Aldoclor Antihypertensive, Thiazide diuretic
Metolazone Diulo Antihypertensive, Thiazide diuretic
Metolazone Mykrox Antihypertensive, Thiazide diuretic
Metolazone Zaroxolyn Antihypertensive, Thiazide diuretic
Metoprolol + Hydrochlorothiazide Lopressor HCT Beta-adrenergic blocker, Thiazide diuretic
Minocycline Minocin Antibiotic
Minoxidol Rogaine Hair growth stimulator
Nabilone Cesamet Antiemetic, Antinausea
Nadolol + Bendroflumethiazide Corzide Antihypertensive, Beta-adrenergic blocker
Nalidixic Acid NegGram Antimicrobial
Naprosyn Anaprox NSAID,* antiarthritic
Naprosyn Naproxen NSAID,* antiarthritic
Nifedipine Adalat Antianginal, Antihypertensive, Calcium channel blocker
Nifedipine Procardia Antianginal, Antihypertensive, Calcium channel blocker
Norfloxacin Noroxin Antibacterial
Nortriptyline Pamelor Antidepressant (tricyclic)
Oxytetracycline Terramycin Antibiotic
Perphenazine Trilafon Antipsychotic, Tranquilizer
Perphenazine + Amitriptyline Etrafon Antidepressant (tricyclic) Tranquilizer
Phenylbutazone Butazolidin NSAID,*antiarthritic
Phenylpropanolamine + Chlorpheniramine Ornade Spansule Antihistamine, Decongestant
Phenylpropanolamine + Pheniramine + Pyrilamine Triaminic TR Decongestant, Antihistamine
Phenytoin Dilantin Anticonvulsant
Piroxicam Feldene NSAID,* antiarthritic
Polythiazide Renese Antihypertensive, Thiazide diuretic
Prazosin + Polythiazide Minizide Antihypertensive, Thiazide diuretic
Prochlorperazine Compazine Antinausea, Anti-vomiting
Promethazine Phenergan Antihistamine
Propranolol + Hydrochlorothiazide Inderide Beta-adrenergic blocker, Thiazide diuretic
Protriptyline Vivactil Antidepressant (tricyclic)
Pyrazinamide Pyrazinamide Anti-infective, Antituberculosis
Quinethazone Hydromox Antihypertensive, Diuretic
Quinidine Gluconate Quinaglute Dura-Tabs Antiarrhythmic
Quinidine Sulfate Quindex Extentabs Antiarrhythmic
Quinidine Sulfate Quinora Antiarrhythmic
Quinine Quinamm Antiprotozoal
Rauwolfia + Serpentina + Bendroflumethiazide Rauzide Antihypertensive, Thiazide diuretic
Reserpine + Chlorothiazide Diupres Antihypertensive, Thiazide diuretic
Reserpine + Hydrochlorothiazide Hydropres Antihypertensive, Thiazide diuretic
Reserpine + Hydrochlorothiazide Serpasil-Esidrix Antihypertensive, Thiazide diuretic
Reserpine + Hydralazine + Hydrochlorothiazide Ser-Ap-Es Antihypertensive, Thiazide diuretic
Selegiline Eldepryl Anti-Parkinsonism, MAO inhibitor
Spironolactone + Hydrochlorothiazide Aldactazide Antihypertensive, Thiazide diuretic
Sulfacytine Renoquid Antibiotic
Sulfadoxine + Pyrimethamine Fansidar Antimalarial, Antiprotozoal
Sulfamethizole + Phenazopyridine Thiosulfil-A Urinary analgesic, Antibiotic
Sulfamethoxazole Gantanol Antibiotic
Sulfamethoxazole + Phenazopyridine Azo Gantanol Antibiotic, Urinary analgesic
Sulfapyridine (Generic only) Dermatitis herpetiformis suppressant
Sulfasalazine Azulfidine Bowel anti-inflammatory
Sulfinpyrazone Anturane Antigout agent, Antihyperuricemic
Sulfasoxazole Gantrisin Antibiotic
Sulfasoxazole + Phenazopyridine Azo Gantrisin Antibiotic, Urinary analgesic
Sulfone Dapsone Antileprosy, Antimalarial
Sunlindac Clinoril (<1%) NSAID,* antiarthritic
Terfenadine Seldane Antihistamine
Tetracycline Achromycin Antibiotic
Thioridazine Mellaril Antipsychotic, Tranquilizer
Thiothixene Navane Antipsychotic, Tranquilizer
Timolol + Hydrochlorothiazide Timolide Beta-adrenergic blocker, Thiazide diuretic
Tolazamide Tolinase Antidiabetic (oral), Sulfonylurea
Tolbutamide Orinase Antidiabetic (oral), Sulfonylurea
Tretinoin Retin-A Antiacne (topical)
Triamterene Dyrenium Antihypertensive Diuretic
Trifluoperazine Stelazine Antipsychotic, Tranquilizer
Triflupromazine Vesprin Antiemetic, Antipsychotic
Trimeprazine Temaril Antipsychotic, Tranquilizer
Trimethoprim Trimpex Antibiotic
Trimethoprim + Sulfamethoxazole Bactrim Antibiotic
Trimethoprim + Sulfamethoxazole Septra Antibiotic
Trimipramine Surmontil Antidepressant (tricyclic)
Tripelennamine PBZ Antihistamine
Triprolidine Actidil Antihistamine
Triprolidine + Pseudoephedrine Actifed Antihistamine, Decongestant
Visblastine Velban Antieoplastic

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